The foundation of our research is the development of chemical tools and methods with applications that span from medicinal chemistry to radiological sciences. The lab takes an interdisciplinary approach, combining elements of organic synthesis, catalysis, and biology to address problems of clinical importance. We maintain a fundamental interest in designing metal-catalyzed processes to construct structural motifs embodied in molecules of biological and therapeutic significance. Using such chemical technologies, we are also developing molecular probes for hyperpolarized 13C MR and PET imaging to discover and study new questions in cancer and neurobiology.
Synthesis and Biological Evaluation of Enzyme Modulators
Development of Metal-Catalyzed Transformations for Organic Synthesis
Design and Application of Metabolic Imaging Probes for Hyperpolarized 13C Magnetic Resonance Spectroscopy